The biochemical machinery of human cells is designed to see breaks in the DNA ribbon as “defects” and to glue the loose ends together again. Publications | CV. Site Map | Past Members. Heineken Prize for Biochemistry and Biophysics for her research on telomeres, the protective elements located at the tips of chromosomes, which play a crucial role in ageing and cancer. Comments | de Lange, Titia Leon Hess Professor Laboratory of Cell Biology and Genetics E-mail: Laboratory of Cell Biology and Genetics. Contact | Telomeres, the nucleoprotein complexes at the natural ends of chromosomes, protect chromosome ends and ensure their complete replication. The loss of telomere protection is the cause of the premature aging symptoms associated with Dyskeratosis congenita and … All rights reserved. Medical Sciences, Systems Physiology, and Human Genetics, Physical, Mathematical, and Computational Biology, Stem Cells, Development, Regeneration, and Aging, Tri-Institutional and External Collaborations, Center for Basic and Translational Research on Disorders of the Digestive System, Center for Studies in Physics and Biology, Christopher H. Browne Center for Immunology and Immune Diseases, Fisher Center for Alzheimer's Disease Research, F.M. Research in the de Lange lab focuses on human and mouse telomeres, which are made up of long arrays of double-stranded TTAGGG repeats that end in a single-stranded 3′ overhang. Fax: (212) 327 7147. e-mail: Titia de Lange Leon Hess Professor American Cancer Society Professor Head of Laboratory of Cell Biology and Genetics Director, Anderson Center … Susan Smith* and Titia de Lange Human telomeres are maintained by telomerase, a reverse transcriptase that adds telomeric repeats to chromosome ends [1,2]. Year Citation Score; 2018: Mirman Z, Lottersberger F, Takai H, Kibe T, Gong Y, Takai K, Bianchi A, Zimmermann M, Durocher D, de Lange T. 53BP1-RIF1-shieldin counteracts DSB resection through CST- and Polα-dependent fill-in. The lab identified a six-subunit protein complex, which they named shelterin, that specifically binds to telomeres. Titia de Lange has been awarded the 2012 Dr H.P. Current Members. Copyright Complaints. E-mail: delange{at} Titia de Lange; Laboratory of Cell Biology and Genetics, Rockefeller University, New York, NY 10021, USA. Barnes, Stewart Laboratory Administrator E-mail: Cai, Sarah Graduate Fellow E-mail: de Lange, Titia Professor Head of Laboratory E-mail:… Using genetic approaches, de Lange and her colleagues determined […] Copyright © 2004–2020 The Rockefeller University. Michal Zimmermann 1 , Titia de Lange 2 Affiliations 1 Laboratory for Cell Biology and Genetics, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA; Central European Institute of Technology and Faculty of Science, Masaryk University, Brno, Czech Republic. In human tumors and immortalized cells, telomeres are often maintained at a constant length setting [3,4], indicating that telomerase-mediated telomere elongation is tightly regulated. Kirby Center for Sensory Neuroscience, Pels Family Center for Biochemistry and Structural Biology, Shelby White and Leon Levy Center for Mind, Brain and Behavior, Center for Clinical and Translational Science. Titia de Lange; Current Members; Past Members; Protocols; Reagents; Contact; Laboratory for Cell Biology and Genetics Telomeres. Titia de Lange Titels: Prof. dr. Initials: T. Main position: Hoogleraar Rockefeller University: Disciplines: Histology, cell biology: Chair: Cell Biology and Genetics: Domain: Medical, Biomedical and Health Sciences: Membership: Correspondent : Since: 2000: Member of Jury of the Dr H.P. Leon Hess Professor American Cancer Society Professor Head of Laboratory of Cell Biology and Genetics Director, Anderson Center for Cancer Research The Rockefeller University 1230 York Avenue New York NY 10065 Phone: (212) 327 7464 Fax: (212) 327 7147 e-mail:, The Rockefeller University | 1230 York Avenue, New York, NY 10065 | 212-327-8000