Add 1.5 mL of phosphoric acid, and further adjust with phosphoric acid or potassium hydroxide solution to a pH of 2.5 ± 0.1. 0000004306 00000 n 0000003758 00000 n 0000054386 00000 n Great things happen when the world agrees. Calculation of the three amounts a), b), and c). 0000001763 00000 n ASSAY—HPLC and UHPLC (isocratic method) Buffer: Dissolve 7.2 g of monobasic potassium phosphate in 1,000 mL of water. 0000054179 00000 n Any use, including reproduction requires our written permission. 0000006176 00000 n Cool, and transfer the solution to a conical separator with the aid of 20 mL of water. - Replaces ISO Recommendation R 990-1969. H���Ao�0���輻�WZJɌ "�8�i. Opening hours: W�?��N���R�J��7�A�����a��y�bx+o�.�C�,�y}�؝ ���V׮�U�~{����3-���i����qʀT�Nƿ�9E�wG�v^g���v1]�Xş�/��b�Y�#� 4�� endstream endobj 348 0 obj << /Type /FontDescriptor /Ascent 891 /CapHeight 0 /Descent -216 /Flags 34 /FontBBox [ -568 -307 2028 1007 ] /FontName /BHHJIB+TimesNewRoman /ItalicAngle 0 /StemV 0 /FontFile2 366 0 R >> endobj 349 0 obj << /Type /Font /Subtype /TrueType /FirstChar 32 /LastChar 32 /Widths [ 250 ] /Encoding /WinAnsiEncoding /BaseFont /BHHJIB+TimesNewRoman /FontDescriptor 348 0 R >> endobj 350 0 obj 389 endobj 351 0 obj << /Filter /FlateDecode /Length 350 0 R >> stream 0000046358 00000 n 0000001271 00000 n Method for determination of the titre, conventionally expressed as percentages by mass of KOH. 0000005725 00000 n �H� endstream endobj 344 0 obj 349 endobj 345 0 obj << /Filter /FlateDecode /Length 344 0 R >> stream 0000007629 00000 n The principle consists in titration of the total alkalinity with standard volumetric hydrochloric acid solution in the presence of methyl orange as indicator. International Standard under periodical review, All ISO publications and materials are protected by copyright and are subject to the user’s acceptance of ISO’s conditions of copyright. Any use, including reproduction requires our written permission. 0000007138 00000 n 0000002067 00000 n H���]k�0���+r�.�tZ�at��߯�!4�E���I��Gt��c'ƓX����M�d$���X��9���[�. 3kPdm�.�m@��8�b+d`u[��ᘟw�i�/t�X_��m��A��ǝ�0�� ��� endstream endobj 346 0 obj 433 endobj 347 0 obj << /Filter /FlateDecode /Length 346 0 R >> stream 0000008709 00000 n H���]o�0��������|Z�*��n���-�`�]a�j�~6�c�`�����y_��ؚ�ݝ��0��?D�a�)�B��~@�A@�a-�6o��mU�ojQ@-���S�aeٳq�ƘAV�Q�^�؈-�Q� >��R�A�3F�Y6N��>/����4����2&�1����]r�۩�N�`d��iU[E|VlG^�� |�&j��t �#��J�7�>"�V�]z�C��ؿ��������Uah6e�X���!o��p ����$|�jD����~l�ܨ�D I�H�u�uoeB^�a�N-i�� �����[���>G��1��K�팮L1o�l1y-y�:K�y!�E�z�*%��EȋIW��F�P�}Zb\�8�BY5�;��D����5��e���w�_��S5 �{�ԓ�;�ko^2pd��p����E�3ڑ�gG�[b�Lf�2N�~���t������*��A6*�}��rss��Ⰳ��u�7�#L�� Abstract. 0000003010 00000 n Add 112.2 g KOH to 900 mL of deionised water and dissolve by stirring. 1.2 The analytical procedures appear in the following order: Alkalinity (Total), Titrimetric (for 50 to 100 % 0000004861 00000 n 0000003231 00000 n 0000001625 00000 n 0000003717 00000 n Assay-methods | Pharmaceutical analyses Ph. 0000005747 00000 n There are three ways: a) total alkalinity, b) caustic alkalinity corresponding to the total alkalinity less the alkalinity due to carbonates and c) actual potassium hydroxide corresponding to the total alkalinity less the alkalinity due to carbonates and any hydroxide which may be present. 0000003261 00000 n [Note: May be used as an aqueous solution.] If you have any questions or suggestions regarding the accessibility of this site, please contact us. �����o�ɂm#�]�? %PDF-1.3 %���� 0000008125 00000 n ACID VALUE The acid value IA is the number that expresses, in milligrams the quantity of potassium hydroxide required to neutralise the free acids present in 1 g of the substance. "˥$%���_d���.���%�&.�M=ф7�Tgc��`M\��0��B�����RS�/5h[��U�1K\�����t_e6�+�J�F@!�d�v���>ͳ��xy��U+u�5]�-K��gz:mϹ�������*�qC�s`�(��U!7E�-���iq�LXK�gX�ܟ����F>�t�>��/����˦�8�� ASSAYS 01/2008:20501 2.5.1. 0000002045 00000 n Caustic potash, Lye [Potassium hydroxide], Potassium hydrate Odorless, white or slightly yellow lumps, rods, flakes, sticks, or pellets. Standard Test Methods for Chemical Analysis of Caustic Soda and Caustic Potash (Sodium Hydroxide and Potassium Hydroxide) 1. 0000005085 00000 n �hD�hB"BJv��K�X"��:G�Ryi���Gq͑�9���b(!؇t��w��D������-q͐���M�B���w����YAl��`��� ,�_��E�l����K�ˢ�SS� F^P;�+w�]����dU�Q��d��?�n��z^ 0000007116 00000 n H���]k�0�� ��f����;�B�d,ۚ�Ee�.D�,Y�zX*��~R�nD)_����y��jtgg��z6J���rRW��C��YUa�9�%��%U`�@RI����BJ��Q fW �5���[ػ��u���UMM5����@Z���Gi��JQ) 0000054100 00000 n É grátis para se registrar e ofertar em trabalhos. We are committed to ensuring that our website is accessible to everyone. 0000005107 00000 n 0000006926 00000 n 326 0 obj << /Linearized 1 /O 329 /H [ 1763 304 ] /L 105606 /E 69830 /N 2 /T 98967 >> endobj xref 326 46 0000000016 00000 n This monograph for Potassium Hydroxide provides, in addition to common physical constants, a general description including typical appearance, applications, change in state (approximate), and aqueous solubility. 0000009270 00000 n Assay—Dissolve about 1.5 g of Potassium Hydroxide, accurately weighed, in 40 mL of carbon dioxide-free water. All copyright requests should be addressed to copyright@iso.org. Assay procedure using 0.1N potassium hydroxide Aliquots of asenapine prepared by dissolving different amounts of drug(10-100mg) in 20 ml of methanol was previously neutralized with 0.1N potassium hydroxide ) aliquots were titrated using previously standardized 0.1N potassium hydroxide using 1.1 This test method covers the determination of anionic impurities in 50 % caustic soda (sodium hydroxide) and 50 % caustic potash (potassium hydroxide) solutions using ion chromatography (IC). potassium hydroxide eluent was used for the separation of phosphate and citrate in different pharmaceutical formulations to increase method automation and allow easy method transfer between laboratories.